The ASPIRE Study

Advanced Stratification of People with Depression based on Inflammation.

A study co-designed with people with lived experience.

Research

In collaboration with people with lived experience, we're embarking on a groundbreaking study, led by King's College London, that will revolutionise depression treatment, ensuring that the right treatment reaches the right individuals at the right time.

News & Updates

New ASPIRE Publication in The Lancet Psychiatry

We are delighted to share that our first article from the ASPIRE study, "Anti-inflammatories for depression: challenges and ASPIRations," has been published in the Lancet Psychiatry.

The article explores the growing interest in anti-inflammatory medications as potential treatment for people with the inflammatory subtype of depression. It summarises the current evidence, outlines the challenges that remain, and highlights a way forward for anti-inflammatory drug development in depression.

Read Here

Research

Work Package 1:

Systematic Reviews and Meta-Analyses of Inflammation Related Clinical Predictors

We aim to gather together a large amount of data by thoroughly reviewing the literature investigating anti-inflammatory medications in depression. This includes studies where these drugs were used alone or alongside other treatments. This data will be used to understand whether C-reactive protein, BMI, and specific symptoms (such as changes in sleep and appetite) can predict the response to the anti-inflammatory medications. We will also perform additional analyses to see how factors like age and sex-at-birth affect treatment response.

Team members